PEAQ-ITC

The MicroCal PEAQ-ITC Automated is Malvern Panalytical's unattended-operation ITC platform, built around the same 200 µL cell chemistry as the iTC200 but with an integrated autosampler that loads the cell and syringe, runs the titration, and cleans the system between samples without an operator present. Injection precision is better than 1% at a 2 µL injection, baseline noise is as low as 0.15 ncal/s, and the instrument holds temperature to within ±0.00012 °C across a 2–80 °C working range — precision that matters when comparing small ΔH differences between related ligands.

Sample cell volume: 200 µL

Sample volume per experiment: ~370 µL; syringe volume 40 µL

Injection precision: <1% at 2 µL

Baseline noise: 0.15 ncal/s

Temperature range: 2–80 °C, stability ±0.00012 °C

Operation: fully automated, unattended multi-sample queues

The autosampler is what changes the workflow: instead of one titration at a time, a full set of experiments — a compound series, a set of mutants, a dilution series — can be queued and run unattended overnight or over a weekend. That makes the PEAQ-ITC the platform's default choice whenever more than a handful of titrations are needed for a project, reserving the manual iTC200 for cases where sample is too limited or precious to commit to an automated queue.